CDC Syphilis Among HIV-Infected Persons Treatment Guidelines, 2010

Primary and Secondary Syphilis Among HIV-Infected Persons

  • Recommended Regimen
    Benzathine penicillin G 2.4 million units IM in a single dose

 

Latent Syphilis Among HIV-Infected Persons

  • Recommended Regimens
    Early Latent Syphilis
    Benzathine penicillin G 2.4 million units IM in a single dose
    Late Latent Syphilis or Latent Syphilis of Unknown Duration
    Benzathine penicillin G 7.2 million units total, administered as 3 doses of 2.4 million units IM each at 1-week intervals

Neurosyphilis Among HIV-Infected Persons

  • Recommended Regimen
    Aqueous crystalline penicillin G 18–24 million units per day, administered as 3–4 million units IV every 4 hours or continuous infusion, for 10–14 days
  • Alternative Regimen
    Procaine penicillin 2.4 million units IM once daily
    PLUS
    Probenecid 500 mg orally four times a day, both for 10–14 days

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