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WHO Guidelines for the Treatment of Treponema pallidum (syphilis)

World Health Organization, 2016

Outlines rationale, objectives, target audience, and structure of guidelines for the treatment of Treponema pallidum (syphilis)​

Provides evidence-based recommendations for the treatment of specific clinical conditions caused by T. pallidum which includes early latent, late latent, and congenital syphilis

Supports and provides directions to countries as they develop national treatment recommendations

WHO Global Guidance on Criteria and Processes for Validation: Elimination of Mother-to-Child Transmission of HIV and Syphilis

World Health Organization, 2014

  • Outlines minimum global processes and criteria for validation of EMTCT of HIV and/or syphilis in a country

  • Provides a description of global EMTCT validation targets and indicators

  • Explains the operation of validation committees and secretariats

  • Reviews the validation procedure itself, including maintenance of validation status

WHO Strategic Framework for the Elimination of New HIV Infections Among Children in Africa

World Health Organization Regional Office for Africa, Brazzaville, 2013

  • Outlines the aim, objectives, targets, and priority actions for eliminating new HIV and syphilis infections in children in the African Region by 2015 and keeping their mothers alive

  • Provides countries in the Region with a systematic approach to the elimination of mother-to-child transmission of HIV (EMTCT) based on country typology (epidemiology and response) and improvement of maternal and child health and survival in the context of HIV/AIDS

SRH & HIV Linkages

IAWG on SRH & HIV Linkages, 2012

This resource pack aims to build a common understanding of sexual and reproductive health (SRH) and HIV linkages and provide an overview of the current status of SRH and HIV linkages among key partners. It contains useful resources for organizations advocating for this issue.


The website contains Download links for documents related to elimination of mother-to-child transmission of HIV (EMTCT).

WHO Essential Interventions, Commodities and Guidelines for Reproductive, Maternal, Newborn and Child Health

World Health Organization, 2011

  • ​A global review of the key interventions related to reproductive, maternal, newborn and child health (RMNCH)

UNICEF Elimination of New Paediatric HIV Infections and Congenital Syphilis in Asia-Pacific, 2011-2015: Conceptual Framework & Monitoring and Evaluation Guide

UNICEF East Asia and Pacific Regional Office, Bangkok, 2011

  • Outlines a strategy that HIV, STI, and maternal, newborn, and child health (MNCH) programs in the Asia-Pacific region can adapt to develop country-specific operational plans for a comprehensive national PPTCT and ECS response, with the broader goals of improving maternal and child health and survival in the context of HIV/STIs

PAHO Regional Initiative for Elimination of Mother-to-Child Transmission of HIV and Congenital Syphilis in Latin America and the Caribbean

Pan American Health Organization, 2010

  • Outlines the strategy for the elimination of mother-to-child transmission of HIV and congenital syphilis in the Caribbean

Standards: Prevention of mother-to-child transmission of syphilis

Department of Making Pregnancy Safer, World Health Organization, 2006

  • Part of the Standards for Maternal and Neonatal Care

  • Outlines requirements; input, process and output, and outcome indicators; and the rationale for reducing maternal morbidity, fetal loss and neonatal mortality and morbidity due to syphilis

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WHO Tool to estimate burden of maternal syphilis and adverse outcomes

World Health Organization

WHO has developed a new online tool to estimate the burden of syphilis in pregnancy and associated adverse outcomes using readily available data. This simple tool can be used at a national or a subnational level. The methodologies used in the tools have been reviewed and approved by the Child Health Epidemiology Research Group and used for the recent global estimates. An accompanying set of instructions is available to guide the user through the estimation process.


WHO tool (.xlsx file)

Instructions for use of WHO tool (.pdf file)

CDC Syphilis Treatment and Care Training

Centers for Disease Control and Prevention

Updated Syphilis Clinical Training (August 30, 2013):


Self-Study Module for Clinicians - A web-based training course designed to guide clinicians in the diagnosis, treatment, and prevention of genital HPV infection


Ready-to-use Module for Clinical Educators - A ready-to-use STD curriculum that includes faculty notes, a slide presentation, and student handouts

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